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SecStructPredict

Protein secondary structure prediction


Overview

UGENE provides a set of algorithms for protein secondary structure ( alpha-helix, beta-sheet) prediction from raw sequence within common interactive visual interface. You can access these analysis capabilities for protein sequence using menu Analyse -> Predict secondary structure
Activate SecStructPredict

Current available algorithms:

  • GORIV

    Jean Garnier, Jean-Francois Gibrat, and Barry Robson,"GOR Method for Predicting Protein Secondary Structure from Amino Acid Sequence", in Methods in Enzymology, vol.266, pp. 540 - 553, (1996).

    Improved version of the GOR method in J. Garnier, D. Osguthorpe, and B. Robson, J. Mol. Biol., vol. 120, p. 97 (1978).

  • PsiPred

    Bryson K, McGuffin LJ, Marsden RL, Ward JJ, Sodhi JS. & Jones DT. (2005) Protein structure prediction servers at University College London. Nucl. Acids Res. 33(Web Server issue):W36-38.

    Jones DT. (1999) Protein secondary structure prediction based on position-specific scoring matrices. J. Mol. Biol. 292: 195-202.


You can also take a look at Upcoming features section for future development plans. If you have any feature requests or intresting suggestions please contact the UGENE team (via email or forum).

Usage

After calling Secondary Structure Prediction module, you will see the Prediction Dialog.

SecStructPredict

It supports the following options:

  • Algorithm: you can choose preffered algorithm among available

  • Range selection: select approriate sequence range for prediction

  • Results visual represantion as table

  • To save results as an annotation for current protein sequence press Save As Annotation button

Upcoming features

Several other algorithms (improved Chou-Fassman, JPred and others) are planned to be implemented in next releases. Also internal UGENE BLAST plugin support for PsiPred algorithm is planned.


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